Sign me up!

Subscribe to learn how to break free from stress, exhaustion, overwhelm, hormonal imbalances + weight gain now 👏👏👏

Sign me up!

Subscribe to learn how to break free from stress, exhaustion, overwhelm, hormonal imbalances + weight gain now 👏👏👏

When tiredness turns into fatigue, it’s time to act

August 12, 2025

Lauren Glucina

Trending articles:

GET YOUR COPY →

Learn more →

I'm Lauren Glucina, experienced naturopath, medical herbalist and nutritionist, whose love language is...herbs!

I have a passion for helping professional women navigate chronic stress, exhaustion, nervous system dysregulation and the ensuing hormonal imbalances, so they can thrive in business and in life.

I'm based in Auckland, New Zealand, and am one half of the holistic clinic Herb + Chi. Glad to have you here!

BNatMed, AdDipNutMed, BCS

About Lauren

Feeling burned out? The exhaustion you’re experiencing is your body waving a white flag–a call to slow down, pause and listen in. This blog looks at the difference between tiredness and fatigue, and why fatigue is a time to listen to your body’s needs, and take action.

A professional woman hitting her alarm, struggling to drag herself out of bed in the morning due to chronic fatigue.

Your alarm goes off at 5:45 a.m., like clockwork. But where you once rolled out of bed with barely a grumble, ready to lace up your running shoes and greet the day, now you summon every scrap of willpower just to swing your legs over the side of the mattress.

There’s no sunrise jog anymore—just the long, slow trudge toward another workday, the weight of exhaustion heavy on every step. No matter how many hours you sleep, you wake feeling completely shattered.

And that bone-deep exhaustion doesn’t end when you finally make it out of bed. The morning exhaustion sets the tone for everything that follows. Work becomes an uphill battle, and where you once could push through tiredness, your body now simply refuses to cooperate. By mid-afternoon, you hit a wall so solid that only a nap can carry you through the remaining hours.

This relentless cycle leaves you wondering if life has become nothing more than a painful endurance test — and whether you’ll ever feel like yourself again.

What is the difference between being tired and being fatigued?

What I’ve just described above, illustrates the difference between tiredness and fatigue, with fatigue being one of the hallmarks signs of burnout–your body’s way of asking (sometimes demanding) that you pay attention.

Tiredness is your body’s natural response to using energy throughout the day. It’s temporary and predictable—you feel it building as evening approaches, and it’s beautifully resolved by a good night’s sleep. Your body is remarkably resilient at replenishing energy stores when given proper rest.

Fatigue tells a different story entirely. Here, there’s a deeper metabolic struggle happening. Once your energy reserves run low, your body can’t seem to replenish them effectively, even with adequate rest, time off, or sleep. It’s a persistent, lingering exhaustion that doesn’t respond to the usual remedies and can significantly impact your daily life.

🧘 Being in tune with your body and recognising the difference between tiredness and fatigue helps you safeguard your well-being by knowing when to rest and restore versus when you can safely push through.

What’s really happening

Now that we know how tiredness differs from fatigue, it’s worth understanding what’s happening beneath the surface when rest and sleep don’t restore your energy.

In the case of burnout-related fatigue, we’re looking at biological disruptions across multiple body systems, all stemming from chronic, unrelenting stress.

Cortisol rhythm disruption

Despite what social media might suggest, cortisol isn’t the bad guy—it’s actually essential for healthy functioning. In a balanced state, cortisol follows a beautiful daily rhythm: levels peak in the morning to help you feel alert and energised, then gradually decline throughout the day, stepping aside as melatonin prepares you for sleep.

With chronic stress, the Hypothalamic-Pituitary-Adrenal (HPA) axis—the system that regulates our stress response—becomes dysregulated, disrupting our natural cortisol rhythms.

You might find yourself lacking that morning cortisol boost, leaving you feeling flat, exhausted, and mentally foggy.

Conversely, you may have elevated cortisol in the evening, creating that “tired but wired” feeling that makes sleep elusive.

🔬 Your daily cortisol rhythm can be measured with a simple salivary test, using samples collected at different times throughout the day. This helps identify whether any HPA axis dysfunction is present.

Circadian rhythm disruption

When your cortisol rhythm is off-balance, your internal body clock—your circadian rhythm—suffers too. This affects far more than just sleep. Circadian disruption can be caused by various factors including chronic stress, irregular light exposure, shift work, caffeine consumption, and even eating late at night.

When this happens, melatonin production becomes compromised—it may be delayed, reduced, or shortened in duration. This not only contributes to insomnia and daytime fatigue but can also lead to increased blood pressure, elevated blood glucose and insulin levels, and greater risk of metabolic dysfunction.

🔬 The daily cortisol rhythm test mentioned above can help give us insights into circadian misalignment, while wearable devices can provide data on sleep quantity and quality.

Inflammation and nutrient absorption issues

Chronic inflammation—whether from prolonged stress, infections, injuries, or environmental toxins—can significantly impact your energy production. It disrupts how your cells create energy, increases your body’s energy demands, and can even interfere with sleep patterns.

When inflammation affects your digestive system, it can impair your body’s ability to absorb essential nutrients. Deficiencies in vitamin B12, iron, magnesium, and vitamin D can all contribute to fatigue and mimic symptoms of burnout.

🔬 Inflammatory markers and key nutrients can be assessed via a blood test.

Mitochondrial dysfunction

Think of mitochondria as tiny powerhouses within your cells—they convert food and oxygen into usable energy (ATP) that runs your entire body. Circadian disruption, inflammation, oxidative stress, toxins and nutrient deficiencies can all slow down this vital energy production process.

In severe cases, when your body perceives itself to be under significant threat (whether physical or psychological), your cells may actually enter a protective “hibernation” mode, dramatically reducing ATP production. In these instances, there simply isn’t enough energy being created to meet your body’s demands, you are truly running at a deficit.

🔬 Mitochondrial energy production can be assessed via an organic acids test.

Blood sugar imbalances

Blood sugar fluctuations can be both a cause and consequence of fatigue. Chronic stress affects this delicate balance since cortisol, glucose, and insulin are intimately connected. When blood sugar spikes and crashes throughout the day, your energy levels follow the same roller coaster pattern.

These imbalances can also disrupt sleep—they’re often the culprit behind those frustrating 3 a.m. awakenings. Beyond energy crashes, signs of blood sugar imbalance include feeling foggy or hungry shortly after eating, irritability between meals, cravings for sweets and refined carbohydrates, and episodes of dizziness or light-headedness.

🔬 You can assess your body’s ability to manage glucose in several ways, from simple blood tests to using a continuous glucose monitor.

Fatigue is physiological, not personal

Have hope! Fatigue isn’t a character flaw—it’s your body’s physiological response to hormonal and metabolic imbalances that have developed over time across multiple systems.

Think of fatigue as your body’s wisdom in action, signaling that deeper systems need support and care. This is an invitation to honour your body’s needs: slow down, protect your precious energy, and prioritise rest in whatever form resonates with you—whether that’s meditation, time in nature, reading, gentle yoga, or simply listening to music.

💗 Most importantly, practice self-compassion. There’s no need for self-criticism when you can’t push through. Remember: while you might power through ordinary tiredness, fatigue will always push back.

Holistic solutions

If you’d like personalised support to address burnout and chronic fatigue, please book in a naturopathic consult–I’m here to help. Together, we’ll explore the underlying causes and contributing factors, and create a bespoke plan to get you feeling like yourself again.

Till next time,
Lauren. 🤍

Comments +

Leave a Reply

Your email address will not be published. Required fields are marked *

The information provided in this blog is for your personal or other non-commercial, educational purposes. It should not be considered as medical or professional advice. We recommend you consult with a GP or other healthcare professional before taking or omitting to take any action based on this blog. While the author uses best endeavours to provide accurate and true content, the author makes no guarantees or promises and assumes no liability regarding the accuracy, reliability or completeness of the information presented. The information, opinions, and recommendations presented in this blog are for general information only and any reliance on the information provided in this blog is done at your own risk. 

Must-Reads

When tiredness turns into fatigue, it’s time to act

When tiredness turns into fatigue, it’s time to act

When tiredness turns into fatigue, it’s time to act

Must-Reads

hey there!

I'm Lauren Glucina, experienced naturopath, medical herbalist, nutritionist, and wellness coach whose love language is...herbs!

I have a passion for helping professional women navigate chronic stress, exhaustion, nervous system dysregulation and the ensuing hormonal imbalances, so they can thrive in business and in life.

I'm based in Auckland, New Zealand, and am one half of the holistic clinic Herb + Chi. Glad to have you here!

BNatMed, AdDipNutMed, BCS


About Lauren

Meet the author

Your Information is 100% secure and will never be shared with anyone. You can unsubscribe at any time. View the privacy policy here.

Get my ultimate guide to hormone-balancing breakfasts: Fix your metabolism, without the deprivation.🤸

HEAL YOUR METABOLISM